What is a potential effect of using long-term high-dose inhaled corticosteroids?

Long-term use of high-dose inhaled corticosteroids can lead to systemic side effects and growth suppression due to the systemic absorption of the medication, although they are primarily intended to act locally within the lungs. Corticosteroids are known to have a variety of effects because they can influence metabolic processes and immune function throughout the body when used at high doses.

One of the significant concerns with prolonged high-dose exposure is the potential impact on growth in children, as corticosteroids can inhibit the body's natural growth hormones, leading to stunted growth over time. Additionally, systemic side effects may include alterations in blood sugar levels, increased risk of osteoporosis, and impacts on adrenal function, as the body may reduce its own cortisol production due to the negative feedback mechanism triggered by external corticosteroids.

While inhaled corticosteroids are effective at reducing inflammation and improving lung function in the short term, their long-term high-dose use necessitates careful monitoring for these adverse effects, particularly in pediatric patients, to minimize the risk of long-term complications.